I think it just depends on how it is served. If it is something non-organic, like shoved in between every other post it would have a negative effect.
Superbowl ads work because people are willing to watch it. It’s part of the game and made to entertain. But when’s the last time you actually bought something advertised on the Superbowl ads?
I don’t think there are a lot of people that enjoys an ad on a YouTube video one minute and fifteen seconds into the video you are trying to watch.
Hopefully you don’t have any rogue mods. Apprently r/adviceanimals got the head mod replced by someone that seems to be more inline with the admins-reddit. (u/legweed -> u/CedarWolf)